Imas New Concept for Continuous Manufacturing

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IMA S.p.A. - IMA ACTIVE division

IMA INDUSTRIES S.R.L Unipersonale

Direct Compression will be the Future Technology

Gaining a clear picture of the market is essential while developing future technologies. Some companies aim at massive production running 24 hours, seven days a week, for more than 50 weeks a year, with minimum downtime. Other requirements pursue flexible production, which requires a small footprint and a highly-automated process. The end goal of adopting a continuous process is not necessarily about achieving high volume throughput, but about pursuing lean and consistent manufacturing that builds quality into the product, rather than testing at the end.

Facing a similar scenario, Ima ­Active has decided to make a choice projected towards the future, where most of oral solid dosage forms are produced by direct compression whereas at the moment most of the solid oral forms are produced by wet granulation. The main goal of this initiative is to rapidly take to the market a complete solid dose ­processing line for direct compression.

Some existing technologies for oral solid forms are inherently continuous — milling, tableting, capsule filling. Others — like mixing and coating — need to be modified or developed in order to work in a continuous mode. When it comes to technologies for solid oral form production, Ima Active has chosen to start with the tablet coating process because it comes between two intrinsically continuous processes already managed by Ima machines: tablet pressing and packaging. Croma, the new continuous tablet coating equipment, is sized to work downstream of a medium-speed tablet press.

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