Milling of Active Ingredients: A Matter of Heartfelt Importance

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Milling Active Ingredients – A Most Important Manner

The system is located in a room that complies with Atex Zone 2/22 T4 IIB regulations. In order to comply with all process regulations (including Atex), the procedure below should be followed:

The Big Bag outlet should be attached to the discharge station inlet, before the Big Bag is earthed. It can then be securely docked using the inflatable gasket.

Next, the Profi-Vent valve should be opened to begin rendering the system inert. Once the oxygen level falls below 5 %, the mills can be activated and the Big Bag can be opened. A vibrator can improve the fluidity of a poorly flowing product. After the Big Bag has been completely emptied, the mills and inert device must be turned off.

The ground floor dosage gate valve should be closed and the container removed; on the first floor, the Profi-Clean must be closed to open the inflatable gasket and remove the Big Bag. The oxygen sensor should be quickly cleaned with nitrogen each time a Big Bag is changed.

Accurate analysis of the process results and process optimisation are possible thanks to the use of statistical analysis. In some individual experiments, it provides accurate information about the correlation between influencing factors and target variables. During the process analysis, the user is guided through the entire optimisation process, from the design phase to the analysis of data.

Conclusion: Frewitt has left nothing to chance — from the evaluation of the system, through installation and to cleaning and rendering inert, it has all been thought out in detail. As we know, there is a reason for this: To ensure the manufacture of the best quality medication, medication to prevent greater evils. The milling of active ingredients is therefore not only a matter of the mind but also a matter of heartfelt importance.

* The author is Marketing Director, Frewitt SA, Granges-Paccot/Switzerland

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