Milling Milling of Active Ingredients: A Matter of Heartfelt Importance

Author / Editor: René Herzog / Dominik Stephan

Every day, a team of more than 3,000 researchers in a particular pharmaceutical factory attempt to improve the effectiveness of medication. This article will highlight how the effectiveness of process steps is also closely examined, which may at first appear insignificant — especially milling.

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The heart of the system: Coniwitt and Hammerwitt milling systems
The heart of the system: Coniwitt and Hammerwitt milling systems
(Picture: Frewitt)

Almost one in every two deaths in Germany is related to cardiovascular disease. Pharmaceutical manufacturers are therefore always researching new treatments and creating more effective medication. Medication helps to prevent people with high blood pressure from suffering a heart attack or a stroke. In 2008 alone, a big pharmaceutical manufacturer produced more than 750 million packets of medication. Along with medication to fight against heart and venous disease, the company also manufactures medication for rheumatism and other illnesses.

The most important target for the pharmaceutical manufacturer is simply to be able to process active ingredients and carriers with different product properties. The process consists of: emptying Big Bags; milling the product; and filling the containers.


Involve the Equipment Manufacturer from the Start

As the pharmaceutical company already had Frewitt equipment installed, Frewitt was involved in the evaluation phase. The Frewitt factory has a technical center with an analytical laboratory, which is valuable when testing customer products. The results can be analyzed and the in-house processes optimized. The advantage of the procedure mentioned, practical results, convinced the Frewitt customer to opt for two milling systems, the Coniwitt 200 conical sieve mill and the MFH-6 hammer mill, which would be connected in series.

A Multi–Purpose Milling System

To provide a better understanding of the system, it should first be described in detail: On the first floor, there is a lifting column, which tilts the Big Bag over the discharge station, where the Big Bag is subsequently docked. The product is gravimetrically transported through the ensuing conical sieve mill (Coniwitt 200) from the Big Bag and subsequently through the Hammerwitt MFH-6.