Dedicated Equipment From Comecer Preserves Isolation When Vials Are Filled

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DÜPERTHAL Sicherheitstechnik GmbH & Co. KG

Lutz Pumpen GmbH

Italvacuum, Srl

Comecer SpA

Balanced air flows for sterility

The crimping cabinet, cap loading container and mouse hole chamber are not physically isolated from the rest of the clean room. Microbiological and particulate contamination are controlled through air flow and filtration, not by rigid barriers.

The HVAC system supplies conditioned air to the crimping cabinet at the correct flowrate and pressure, where it maintains a Class A atmosphere. The HVAC return system then removes a proportion of this air directly from the crimping cabinet, the exact amount depending on the damper settings and fan speeds.

The remaining air flow from the crimping cabinet is drawn into the mouse hole chamber, where it converges with an air stream flowing in the opposite direction from the surrounding Class C area. The combined air is removed by the extraction system.

A pressure transmitter in the crimping cabinet controls the overall system pressure via the PLC, which also provides alarm functions. The crimping cabinet has an anemo- meter to measure the air speed and control the incoming air flowrate from the HVAC system. The mouse hole chamber, whose pressure follows that of the crimping cabinet, has its own pressure sensor.

(ID:22889500)