Freeze Drying Time to Rethink Pharmaceutical Drying
A new method of lyophilisation or freeze drying that uses a single, sterilisable, closed vessel to deliver lump free, fine powder product could have the capability to revolutionise the production of bulk pharmaceutical powders.
With the benefits of improved operator safety, reduced equipment requirements and high quality, contaminant free end product results, the Active Freeze Drying technology from Hosokawa Micron has become a versatile alternative to existing tray type freeze drying methods. In fact, the Active Freeze Drying system is capable of drying solutions, dispersions, pastes and wet solids with successful applications including antibiotics, APIs, proteins, collagens and electrolytes.
The active freeze drying technology incorporates the use of a jacketed and stirred dryer and collection filter. Material is frozen quickly inside the vessel. Energy needed for sublimation is applied through the jacket and distributed efficiently throughout the product by the stirrer which moves the finished dried material, in the form of a fine loose powder to the filter.