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Chromatography

How to Remove Trace Impurities in Chromatography Analytics

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Adsorber Capsule Design

The Sartobind 4 mm capsules looks like a standard filter capsule except that the adsorbing membrane is reeled on a core to form a cylinder, but in the case of Sartobind Pico it has a flat sheet membrane. The flow is from top into the outside channel and then perpendicular through the membrane layers to the center of the cylinder and leaves the capsule at the outlet (Fig 1).

How to Achieve Chemical Compatibility

The housing of Sartobind capsules is polypropylene, which is stable to many standard solvents applied in chromatography. Sartobind ion exchange membranes are compatible with alcohols such as ethanol, isopropanol, glycerol, and denaturing solvents such as 8 M urea and 8 M guanidine HCl and can be cleaned with 1 N sodium hydroxide.

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The robustness of Sartobind IEX membrane adsorbers in ion exchange has been tested in consecutive runs of 1000 chromatographic cycles and the membranes maintain their binding capacity over many cycles reflecting the chemical stability of the ligands.

Installation and Operation

The Sartobind capsules should be installed in the process flow as indicated by an arrow (Pico, Nano, Mini, 20” or 30”) or IN and OUT sign (5” & 10”) on the capsule. During the operation of membrane adsorber small volumes e.g. Pico and Nano hold the unit in an upright position for proper venting (Fig 2).

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