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Diaphragm Pumps in Pharma

How to Choose the Right Pump for Biopharma Manufacture

| Author / Editor: Dr. Andreas Frerix / Dr. Jörg Kempf

Rentschler Biotechnologie is a contract manufacturing organization (CMO) in biopharmaceuticals, creating products for larger firms that need to be manufactured on a small scale or within a very short time frame.
Rentschler Biotechnologie is a contract manufacturing organization (CMO) in biopharmaceuticals, creating products for larger firms that need to be manufactured on a small scale or within a very short time frame. (Picture: Quattroflow)

Rentschler Biotechnologie has built a reputation as one of the biopharmaceutical industry’s top contract manufacturing organizations with the help of Quattroflow quaternary diaphragm pumps. In the company’s new single-use production facility, these pumps’ ability to operate with minimal pulsation helps to keep the process within validation boundaries, especially when it comes to minimizing pressure fluctuations during critical filtration steps.

In the ultra-competitive world of bio-pharmaceutical manufacturing, with billions of dollars in sales at stake, the best friend of large companies like Pfizer, GlaxoSmithKline, Bayer and Roche is often a contract manufacturing organization (CMO). CMOs are called into action when the large conglomerates have a product that needs to be manufactured on a smaller scale or within a very short time frame.

Partnering with a CMO can be a more cost-effective and faster alternative to producing these smaller-scale pharmaceuticals than using their own production facilities.

For nearly 35 years, one of the leading CMOs has been Rentschler Biotechnologie. Headquartered in Laupheim, in south-west Germany between Stuttgart and Augsburg, Rentschler was founded in 1927 as a pharmaceutical manufacturer. Since 1979 the company has been an independent contract manufacturer without its own products, and a specialist in the development and production of active biopharmaceutical ingredients.

Production expertise for Difficult Branches

“Rentschler is a classic CMO,” explains Dr. Markus Laukel, the company’s Associate Director DSP production. “We have production expertise from low-dose cytokines up to higher-dose antibodies, including biosimilars. Even though we are not specialized in any type of production, we produce everything to meet the needs of our customers. In addition to the large manufacturers, we have smaller customers all over the world — the USA, Europe, Asia — that might have no production processes, so they transfer the responsibilities for production to us.”

The Right Pump Helps to Optimize Radial Flow Chromatography

Diaphragm Pumps

The Right Pump Helps to Optimize Radial Flow Chromatography

25/09/2013 - Getting down to the lab: Quattroflow's new single-use quaternary diaphragm pumps are perfectly suited for Radial Flow Chromatography (RFC) systems. RFCs are typically used in biopharmaceutical productions to adsorb and purify Active Pharmaceutical Ingredients (API). read...

Rentschler’s stainless-steel production systems have capacities of 30–2,500 l (8–660 gallons), while single-use production has a scale of up to 1,000 l (264 gallons). As well as cell cultivation and product purification, Rentschler has expertise in formulating and filling the final products.

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