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Coating Pan Coating Highly Humidity Sensitive Products

Editor: Anke Geipel-Kern

Ima Active’s coating pan for film and sugar coating processes helps Glaxo Smith Kline to reduce environmental impact while increasing efficiency. Coating highly humidity sensitive products like antibiotic tablets is challenging. Stable core temperature and the balance of thermodynamic conditions are very important and need to be tested before installing a coating pan. Imas coating pan Perfima for film and sugar coating has made the practical test at the Glaxo Smith Kline site in France.

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Perfima 200 is a flexible and reliable machine providing high efficiency in the field of automatic coating equipment.
Perfima 200 is a flexible and reliable machine providing high efficiency in the field of automatic coating equipment.
(Source: Ima)

As a science-led global healthcare company, Glaxo Smith Kline is specialized in research, development and production of innovative products in three primary areas: Pharmaceuticals, Vaccines, and Consumer Healthcare. GSK has a heritage dating back 300 years. The company was formed with the merger of Glaxo Wellcome and Smith Kline Beecham in 2000.

Today GSK employs nearly 100,000 people around the world covering 150 countries and has an annual turnover of 27.9 billion pounds (2016). Additionally, GSK has a network of 86 manufacturing sites in 36 countries and large R&D centers in the UK, USA, Spain, Belgium and China. GSK is the largest vaccines company, with 833 million vaccines produced in 2016, and is a leading global company tackling respiratory illnesses, infectious diseases and HIV. Beyond the numbers, GSK has vision.

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Coating Pan for Film And Sugar Processes

Research with the special aim to help people do more, feel better and live longer. Close collaboration with doctors and other healthcare professionals is essential for this purpose. The collaboration is solidified by means of contracts and important investments in scientific and technical excellence (3.6 billion pounds R&D investment in 2016). Pursuing the aim to reduce environmental impact while increasing efficiency, Glaxo Smith Kline has equipped its plant in Mayenne (France) with Perfima, Ima Active’s coating pan for film and sugar processes.

Perfima is a flexible and reliable machine. Two models are available: Perfima for tablet film and sugar coating and Perfima Edge for pellet, microtablet, and tablet processing. The shape of the pan combined with the mixing baffles positioned on the central section of the drum ensures a perfect and uniform mixing of the cores. The mixing capability is maintained regardless of minimum or maximum product batch size, allowing a wide range of batch sizes to be processed in the same machine.

Location and dimensions of the outlet air duct are designed to guarantee a good and uniform drying of the product while saving energy.

Perfima spray guns feature an Anti-Bearding-Cap (ABC) system avoiding gun clogging during coating operations. Both film and sugar spray guns can be easily fitted on the sliding support arm and can be manually or automatically positioned and adjusted. The sliding arm can be removed from the front door allowing gun changing, calibration/adjustment with fast and safe cleaning. The spray system and guns should ensure easy maintenance, simple inspection operations and quick changeover from one product to another.

All parts of the machine in contact with the product are completely isolated: the entire coating process can be achieved without contamination of the external environment. In addition, Perfima is equipped with a completely automatic clean-in-place system. Cleaning nozzles and spray balls cover all machine surfaces to be cleaned: the cleaning cycle can start immediately after the coating process without the need to install additional devices.

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