Italy: Dosing in Flexible Formats Accurate Filling of Capsules

Skyepharma, a company specialized in inhalation and oral drugs, uses MG2's Planeta capsule filler for the production of inhalators and modified-release oral products.

Related Vendors

AZO GmbH + Co. KG

CO.RA. S.r.L.

Frewitt fabrique de machines SA

MG2 s.r.l.

Bologna/Italy – The model chosen by Skyepharma is configured to produce 12,000 capsules per hour, but it can be upgraded to manage an output of 25,000 capsules per hour or even up to 100,000 capsule per hour adding a new module.

The two companies met during an industry event, where they laid the foundations for a project leading to the Bolognese manufacturer installing Planeta capsule filler at Skyepharma’s R&D facility near Basel, Switzerland.

MG2 also incorporated a specific micro-dosing unit to enable continuous operation for filling of small masses of powder into capsules (8 to 50 mg) without compaction issues. Further modules to handle different product forms such as pellets, micro tablets, tablets and liquids can also be fitted to this type of machine.

Accurate weight

A capacitive system checks in-process the net fill-weight of each capsule. The real-time self- adjustment system corrects the dosator volume in order to achieve the best fill performance and ensures that the fill-weight of each capsule is within the required acceptance parameters.

Furthermore, the new machine can be scaled-up seamlessly to larger batch volumes.

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