How to Maintain Aseptic Conditions When Filling Vials

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Current practices require the use of Riboflavin (vitamin B2) diluted in water. This substance must be introduced inside the circuit before being submitted to the CIP procedure (Cleaning in place). If there is any residual trace after the washing cycle, the substance acts as a marker indicating whether the washing cycle has been successful or if, on the contrary, the area has not been effectively washed.

Faster, Safer and More Precise

Further advantages are related to the Micro Motion flow meters’ capability to handle versatile multi variable measures. For example, the detection of the temperature is an essential feature for certifying that inside the circuit, during sterilization, you have actually been achieved and maintained the data set by the Customer in PQ phase.

The same flow mass measurement can be used to measure the amount of detergent used. Temperature, density and/or possible presence of foam in the flow measurement have no influence, the mass flow returns the exact amount of detergent that is passed along the circuit.

We can well understand how the batch change is faster than it typically is. In addition to not having to replace the pumps or any other mechanical parts, washing and sterilization phases are done without dismantling measuring instruments. All of that in accordance with GAMP 4 Guidelines and CFR 21-11 Specifications.

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At a glance

How does Micro Motion work?

The Micro Motion mass flow meters are based on a so-called physical principle of Coriolis force (taking its name from the French physicist who studied it extensively in the first half of 1800), which is proportional to the mass of a body in motion in a uniform circular motion. Well, using this principle the Micro Motion mass flow meters allow accurate measurements directly online, that is to say, at the same time as the filling process. In addition to the mass flow rate measurement, the range of Micro Motion tools can also make measurements by volume, density, temperature and concentration, all integrated. Independently from the fluid type to be measured (being a liquid, a gas, sludges, etc.), the environment and/or the type of process to be checked, Micro Motion meters are a reliable, flexible and robust solution fit for solving various needs. They can be installed almost anywhere, as they are flange-type devices. Furthermore, as the drift of parameters is absent, once set, the instrument does not require periodic calibration, as it happens, for example, for load cells. As understandable, the possibility to perform measurements directly in line dramatically improves operating times: the mass flow meter allows running in a single cycle what before was done in separated phases, thus increasing equipment productivity and availability.

A Technology Intended to go a Long Way

The positive experience in the field has led Ima Life management to evaluate further developments linked with mass technology applications on aseptic processing filling machines.

The collaboration with Emerson Process Management has started five years ago, becoming a true partnership. This allowed Ima technicians to be confident on the technical validity of the solution.

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High Level Aseptic Filling

How to Maintain Aseptic Conditions When Filling Vials

Faster, Safer and More Precise

A Technology Intended to go a Long Way