Sustainable Solutions Consortium Develops Process for Large-Scale Production of Antimicrobial Peptides

Source: Press release

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In a joint project, the consortium including mk2 Biotechnologies, Wacker and the Technical University of Munich have developed a scalable and cost-efficient process for the production of antimicrobial peptides (AMPs) based on microbial fermentation.

The project particularly targets the development of new, highly potent AMPs, the development of a planetary circulating solid-liquid reactor, and the integration of both technologies into large-scale bio-production facilities.
The project particularly targets the development of new, highly potent AMPs, the development of a planetary circulating solid-liquid reactor, and the integration of both technologies into large-scale bio-production facilities.
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Munich/Germany – mk2 Biotechnologies, Wacker and the Technical University of Munich (TUM) recently announced their joint project targeting the development, large-scale production and purification of antimicrobial peptides (AMPs) for diverse applications. The project will run for two years. The aim is to take the final steps in rolling out industrially suitable AMPs as a sustainable alternative to artificial preservatives.

Peptides are short amino acid chains, displaying extraordinary properties. For example, antimicrobial peptides, which are also present in the human body, exhibit defensive properties against pathogens. Consequently, these naturally occurring bioactive compounds have demonstrated high potential in applications in personal care, food & beverages, animal breeding and crop protection. In dairy products like yoghurts, AMPs can ensure preservation – a sustainable alternative to established artificial preservatives.

However, due to cumbersome synthesis and the resultant high costs, the potential of AMPs remains mostly unexploited. To make it possible to harvest the potential of AMPs in industrial-scale applications, the consortium aims to develop a scalable and cost-efficient production platform based on microbial fermentation using only sustainable raw materials in the production process. The project particularly targets the development of new, highly potent AMPs, the development of a planetary circulating solid-liquid reactor, and the integration of both technologies into large-scale bio-production facilities.

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“AMPs are a highly interesting product class, which we can produce with our innovative peptide synthesis platform. While providing high activities, conventional technologies have been struggling with large-scale AMP production at sufficiently low costs – a problem we aim to overcome within the joint project,” said Dr. Konstantinos Antonopoulos, managing director of mk2 Biotechnologies GmbH and project coordinator. “Our partners excellently supplement our synthesis processes on all scales, so that we can refine our peptide production platform and develop new, high-efficacy AMPs. Since we are all based in the Greater Munich area, it will be extremely easy to exchange ideas and views. What’s more, we can adapt our partners’ considerable know-how and integrate it promptly into our ongoing development activities.”

“AMPs have an enormous potential to combat a large set of pathogens from families of fungi and bacteria. Together with our partners, we want to make AMPs more readily accessible to the market so that new applications can be developed – for the pharmaceutical sector and beyond,” commented Dr. Oliver Minge, head of innovation at Wacker Biosolutions.

Dr. Karl Glas, scientific director of Water Systems Engineering at the Technical University of Munich (TUM), added: “We are looking forward to providing and jointly optimizing our reactor technology and thereby contributing a disruptive tool for highly efficient solid-liquid reactions in biotechnological processes. We are convinced that we have found excellent partners for the development and integration of the reactor on both lab and large scales. The commercial application of our interdisciplinary process technologies will always be a core target of our research, particularly in the context of novel sustainable approaches like the industrial production of AMPs.”

The project is co-funded by the Bavarian State Ministry for Economic Affairs, Energy and Technology in the context of the “Bayvfp Life- Science Biotechnologie” funding program with up to 980,000 euros.

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