Single Fluid Heat Transfer Systems Are Gaining Importance

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Single fluid heat transfer system is normally connected to the single reactor – where the temperature of the system is varied as per the process requirement, thus maintaining the constant temperature difference between the process and fluid temperature – this gives precise control over heating and cooling rate. Thus, not only the temperature is controlled as a critical process parameter but also the heating-and-cooling time is controlled as a critical parameter – this results in batch to batch consistency and higher yield.

A single fluid system finds its application in a very high temperature reaction, since after the reaction the reaction mixture temperature has to be brought down to the room temperature. The gradual cooling is feasible by selecting the heat transfer area of the secondary system.

Many manufactures of single fluid heat transfer system provide the skid mounted system with PLC-based control. The system can also be designed for specific applications, and engineered and built at site using various components of the system – such as heat exchangers, pumps, sensors, instrumentation and wiring. Multi temperature single fluid systems are also used to cater to various reactors – when the facility has more than one reactor operating at single temperature range.

* The author is the SBU Head (API & BIOTECH) at Spectrum Pharmatech Consultants Pvt. Ltd., India

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