High-Containment Production of APIs and HAPIs: High-Containment Loading and Unloading Systems for Rotary Dryers

Related Vendors

Italvacuum, Srl

DÜPERTHAL Sicherheitstechnik GmbH & Co. KG

TRM Filter d.o.o.

Highly active ingredients (APIs/HAPIs) characterise modern drug production – and place high demands on containment. This article explains how OEL limits and OEB classes influence and control containment technologies and what technical solutions exist for closed transfer systems. Focus: active-passive valves for vacuum dryers that meet OEB 4/5 standards.

In recent years, the production and application of Active Pharmaceutical Ingredients (APIs) and Highly Active Pharmaceutical Ingredients (HAPIs) have met with growing interest. These highly concentrated active substances are used in drug manufacturing and can act on specific cells in the body, proving extremely effective even at very low doses. An increasing number of chemical and pharmaceutical products are being classified in these categories.

Market demands are continuously growing, requiring increasingly advanced equipment, highly qualified personnel, and the implementation of rigorous procedures with targeted safety controls. Equally relevant is the containment of these products. Due to their high concentration, APIs and HAPIs must be handled with extreme care to protect worker safety and minimize waste, considering their high value, both in economic and broader strategic terms.