Search

Process Analytical Technology

PAT is The Key to a Better Process

Page: 3/5

Related Company

“Processes consistently benefit from PAT techniques”

At present, PAT is mainly used in process control : Critical quality attributes are displayed in real time, which makes it possible for the machine operator to intervene with enough time to save a production process if predefined limit values are exceeded during it. Finally, PAT can also be integrated into control circuits and initiate specific process phases when product-specific target values are reached, allowing the operator to achieve a reproducible level of product quality.

Process analytics are in fact an indispensable element of integrating intelligent, advanced process guidance strategies. In order to reduce the cost of implementation, method development, and validation for the user, Glatt works with specialist companies during the development of process-analytical methods.

Gallery

Gallery with 5 images

In doing so, Glatt and its partners Innopharma Technology, Parsum, Sentronic, and Tews Elektronik to provide integrated PAT solutions that cover all current requirements in the production of solids: determining and displaying product moisture, particle size and distribution, as well as the chemical composition and concentration of pharmaceutical mixtures to determine the blend uniformity, for example.

Innopharma Technology has developed a direct imaging system for the real-time, non-destructive measurement of particle size and its distribution in dry and moist granulates and pellets.

Parsum, a specialist in particle measurement technology, has developed the IPP 80 probe to measure particle size distribution in powders, pellets, or granulates in pharmaceutical processes.

The spectroscopy is covered by Sentronic’s diffuse near-infrared reflectance spectroscopy technique, which has been continuously optimized for system solutions in the pharmaceuticals industry over the years.

A Tews Elektronik microwave-based system for real-time monitoring during the process continuously measures surface and core moisture of particles and granulate, regardless of variations in particle size, color, or density. Precise measurement results are achieved in milliseconds.

(ID:44061528)