Precise Measurement New Generation of In-Line Total Cell Density Measurement in Bioprocesses

Hamilton Bonaduz has launched the Dencytee Arc Sensor, a new generation of in-line total cell density biomass measurement. Equipped with two detectors, the solution combines the advantages of transmission and reflection measurement, thus offering higher measurement resolution.

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With the Dencytee Arc sensor, Hamilton Bonaduz presents a new generation of in-line total cell density biomass measurement. Unlike the conventional measurement method of total cell density, where only the transmitted light is measured, the company has taken the measurement technology to the next level and combined the advantages of transmission and reflection measurement.

By upgrading to two detectors, higher measurement resolution can be achieved. This results in higher reliability that can be used in both low and high cell concentrations. The perfect linearity over the entire measuring range from 0 to 200 g/L and accuracy of ± 1 % allows almost complete process monitoring and the establishment of process control, both in real-time, states the company.

Until now, over 85 percent of customers have measured cell density offline. This means a lot of laboratory work, high contamination risk, and inconsistent data quality due to handling errors and/or different operators. As there was no satisfactory alternative so far, users accepted these limitations, mentions the firm.

As a result, optimizing the process and process control previously required a lot of time and a precise understanding of the process. In a 24-hour fermentation, for example, 30 samples, including night samples, are taken over the entire process. Regular process monitoring should ensure that the induction point is not missed, but the process is very labor-intensive for laboratory personnel.

In addition, long working days, as well as shift changes, can influence the results. The outcome is fluctuations in product yield and quality because the process cannot be controlled. All these challenges are now a thing of the past, thanks to the Dencytee Arc Sensor. The use of the probes reduces the number of offline samples, saving both time and money, adds the company.

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