Sensing Electrostatic Behaviour of Pharmaceutical Particles
Using the optimum method to characterise electrostatic behaviour helps to avoid unwanted phenomena as agglomeration, segregation, etc., to improve production processes and product properties.
This review paper firstly discusses the causes and effect of electrostatic charge to the pharmaceutical industry, and then mechanisms by which electrostatic charging occurs. Foremost is tribocharging which arises from particle-particle and particle-wall contacts. Its behaviour is erratic and not easy to predict, nevertheless it is desirable to characterize the charging tendency of pharmaceutical raw materials so that corrective action can be taken prior to full scale manufacture. To this end the principal charge measurement techniques are reviewed.
On the basis of the review it is concluded that there is a need for a practical technique to measure the polarity of individual particles. Finally, a probe for this purpose is described here, whilst its development is the subject of ongoing research.
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