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Tablet Production

How to make Tablet Produktion efficient

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How application technicians can help

Application technicians can also help in cases where the form of the tablet has not yet been finally decided. Here, advice at an early stage is valuable in order to avoid later difficulties. An example: the tablet design is often determined by marketing. But if — regardless of the production conditions — it is exclusively a question of design factors, substantial disadvantages for production can result. This can lead to a production shortfall of up to 100000 pieces per hour or even to a format which cannot be produced at all. With the machine manufacturer’s know-how, optimal avoidance is possible at this point.

Another form of pre-production support is called “scale-up”. Advice in this area is particularly relevant for pharma companies that want to transfer a newly developed tablet as quickly as possible from Galenic development to series production. According to Klatt, “Some customers initiated a special second development phase after the laboratory phase in order to retain the desired tablet, as developed in the laboratory, in the production plant as well. Here we have been able to convince with an instant scale-up from our Galenic press. This means that the parameters of the tablet can be transferred immediately to the chosen machine — with 99 % precision at the first attempt. Complicated simulation calculations, and thus also costs, are eliminated.”

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But also during running production, fine technological adjustments can have enormous effects on the output volume and production quality. The decisive factor is continuous technical support. In tabletting tools, Fette Compacting provides its own mould development and production, with tolerances exeeding those prescribed in the TSM (Tableting Specification Manual) or EU norms. With the FS12 mould format, for example, it is possible to achieve a 40 % improvement in performance at the same pressure dwell time compared to the EU19 format due to the greater number of moulds. Consequently, there is a reduction in down-times, maintenance work and replacement part requirements.

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