Assessing Microbial Metabolism
The application note describes a high throughput analysis of microbial O2 consumption to assess microbial metabolism using MitoXpress, water soluble “mix and measure” O2 sensing probes.
MitoXpress (Luxcel Biosciences) is a water-soluble oxygen-sensitive phosphorescent probe that facilitates microtitre-plate based analysis of microbial oxygen consumption. The ‘mix & measure’ procedure allows rapid and specific detection of microbial oxygen consumption providing a simple yet sensitive means of assessing the impact of a given manipulation on cellular function. Areas of application include, mode of drug action elucidation, screening for antimicrobial compounds, the assessment of bacterial load and the optimisation of culture conditions.
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