01/14/2011 | Autor / Editor: Dr. Harald Stahl / Marion Henig
How to make tablets from potent APIs - Part 2: The overall materials handling concept for potent APIs is the controlling factor in determining the containment performance of the entire installation. There are two basic choices: stainless steel or disposable systems.
Part 1 of this article (“Containment fundamentals” explained that more than half of all new APIs are classified as potent (OEL <10 µg/m3), and that health and safety authorities around the world are strengthening protection for operators who work with these substances.
The article showed why effective containment is always better than personal protective equipment or systems which rely on human behavior, and showed how to calculate the degree of containment required based on occupational exposure limits (OELs), acceptable daily intakes (ADIs) and cross-contamination limits.
In this second article we look at how to choose containment solutions from the huge variety on the market.
A typical tablet process has the following steps:
This article is protected by copyright. You want to use it for your own purpose? Infos can be found under www.mycontentfactory.de (ID: 23777150) | Fotos: Picture: GEA Pharma